eCTD and Standard Locks
In addition to locking folders, you can create eCTD and standard locks.
An eCTD lock prevents you from changing the folder structure and metadata of an assembly. You can create new leaf elements, but you must use the Create eCTD wizard to add, move, and delete folders. In addition, you must use the wizard to change folder metadata. All changes must be made by either unlocking the assembly or using the Create eCTD wizard. This prevents accidental or unauthorized changes that would cause issues with eCTD publishing, but still enables document assignment and leaf manipulation.
A standard lock prevents most changes to the assembly, including changes to folders, leaf elements, documents, and publishing elements. However, you may still change document binding; binding must be locked separately.