Cumulative index.xml Elements

• If the previous sequence was 0000, the appropriate path information is added to the hrefs for the leaf elements so you can navigate from the submission number folder to the 0000 sequence folder ( ../0000/ is added to the beginning of the file path).
• The current sequence number is added to the href of all leaf elements in the current sequence ( ../xxxx is added to the beginning of the file path).
• If replace operations were performed on leaf elements, only the leaf elements in the current sequence are included. The modified file reference refers to the leaf elements in the earlier sequence.
• If append operations were performed on leaf elements, the leaf elements from the earlier sequences are included in the XML, as well as the appended leaf elements in the current sequence. The leaf in the current sequence follows the leafs from the earlier sequences in the XML file.
• If new operations were performed on leaf elements in the current sequence, these elements are included. Effective leaf elements previously submitted in the same eCTD element are also included.
• If a delete operation was performed on a leaf element in a previous sequence, only one leaf element representing the element in the current sequence is included. The modified file references the leaf element in the previous sequence. The xlink:href and checksum attributes are blank because no file is submitted.
• A leaf for the jp-regional-index.xml is included in the index.xml. The replace operation applies to all sequences after 0000. The modified file references the prior sequence’s jp-regional-index.xml file.
• The checksum for jp-regional-index.xml is calculated and included in the index.xml file as the appropriate leaf attribute for that file.

Other Results

• The jp-regional-index.xml, index.xml, and index-md5.txt files are prefixed with c- and placed in the output location you chose in CVB. (Remove the prefix c- before using the cumulative files.)
• The checksum for index.xml is calculated and written to the index-md5.txt file and placed in the output location you specified.
• Any errors are written to an error log file, which is also saved in the output folder you specified.